4-(吲哚-1-基)哌啶甲酸叔丁酯合成路线 （共 12 条）
反应条件
1: in dichloromethane T=20°C; 1 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 24 p. 6773 - 6776
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran T=0 - 5°C; 0.75 h;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
sodium tris(acetoxy)borohydride in acetic acid T=50°C; 18 h;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
triethylamine in dichloromethane
参考文献
US5545636 A1, ;
US 5545636 A
反应条件
1: 84 percent / TMSCl / 22 h / Heating 2: 100 percent / H2 / Pd/C / methanol / 20 °C / 1034.3 - 2585.74 Torr 3: 92 percent / NaBH(OAc)3 / acetic acid / 18 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 100 percent / H2 / Pd/C / methanol / 20 °C / 1034.3 - 2585.74 Torr 2: 92 percent / NaBH(OAc)3 / acetic acid / 18 h / 50 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 99 percent / NaBH(OAc)3 / acetic acid / 1 h / 20 °C 2: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 99 percent / NaBH(OAc)3 / acetic acid / 1 h / 20 °C 2: 88 percent / DDQ / tetrahydrofuran / 0.75 h / 0 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 36 p. 7215 - 7229
反应条件
1.1: 70 percent / TFA / ethyl acetate / 12 h / 60 °C 2.1: 97 percent / K2CO3 / dimethylformamide / 5 h / 20 - 50 °C 3.1: HCl gas / acetonitrile / 0.5 h / 0 - 20 °C 3.2: acetonitrile / 2 h / -10 - 0 °C 3.3: 86.5 percent / acetonitrile / 1 h / -10 - 0 °C 4.1: 75 percent / t-BuOK / tetrahydrofuran / -5 - 45 °C View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
反应条件
1: 70 percent / TFA / ethyl acetate / 12 h / 60 °C
2: 49 percent / K2CO3 / dimethylformamide / 20 °C
View Scheme
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
