反应条件
1: 1.) K2CO3, 2.) 2.5 N NaOH / 1.) DMF, 55 deg C, 1 8 h, 2.) methanol, reflux, 4 h 2: 1.) thionyl chloride, 2.) triethylamine / 1.) DMF, reflux, 4 h, 2.) RT, overnight 3: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 3 h / Ambient temperature View Scheme
参考文献
Huang, Horng-Chih; Li, James J.; Garland, Danny J.; Chamberlain, Timothy S.; Reinhard, Emily J.; Manning, Robert E.; Seibert, Karen; Koboldt, Carol M.; Gregory, Susan A.; Anderson, Gary D.; Veenhuizen, Amy W.; Zhang, Yan; Perkins, William E.; Burton, Earl G.; Cogburn, J. Nita; Isakson, Peter C.; Reitz, David B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 253 - 266
