2-甲氧基-6-(三甲基硅烷基)吡啶合成路线 （共 7 条）
反应条件
1: tBuLi 2: nBuLi, I2 3: 63 percent / Et3SiH / trifluoroacetic acid 4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2 5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3 6: 47 percent / ICl 7: 72 percent / aq. HI 8: NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide 9: Me3SnSnMe3 / benzene / 70 °C / Irradiation View Scheme
参考文献
Curran, Dennis P.; Ko, Sung-Bo; Josien, Hubert
Angewandte Chemie, 1995 , vol. 107, # 23/24 p. 2948 - 2950
反应条件
1: tBuLi 2: nBuLi, I2 3: 63 percent / Et3SiH / trifluoroacetic acid 4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2 5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3 6: 47 percent / ICl 7: 72 percent / aq. HI 8: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide 9: Me3SnSnMe3 / benzene / 70 °C / Irradiation View Scheme
参考文献
Curran, Dennis P.; Ko, Sung-Bo; Josien, Hubert
Angewandte Chemie, 1995 , vol. 107, # 23/24 p. 2948 - 2950
反应条件
1: tBuLi 2: nBuLi, I2 3: 63 percent / Et3SiH / trifluoroacetic acid 4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2 5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3 6: 47 percent / ICl 7: 72 percent / aq. HI 8: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide 9: Me3SnSnMe3 / benzene / 70 °C / Irradiation View Scheme
参考文献
Curran, Dennis P.; Ko, Sung-Bo; Josien, Hubert
Angewandte Chemie, 1995 , vol. 107, # 23/24 p. 2948 - 2950
反应条件
1: tBuLi 2: nBuLi, I2 3: 63 percent / Et3SiH / trifluoroacetic acid 4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2 5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3 6: 47 percent / ICl 7: 72 percent / aq. HI 8: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide 9: 51 percent / Me3SnSnMe3 / benzene / 70 °C / Irradiation View Scheme
参考文献
Curran, Dennis P.; Ko, Sung-Bo; Josien, Hubert
Angewandte Chemie, 1995 , vol. 107, # 23/24 p. 2948 - 2950
反应条件
1: tBuLi 2: nBuLi, I2 3: 63 percent / Et3SiH / trifluoroacetic acid 4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2 5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3 6: 47 percent / ICl 7: 72 percent / aq. HI 8: NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide 9: Me3SnSnMe3 / benzene / 70 °C / Irradiation View Scheme
参考文献
Curran, Dennis P.; Ko, Sung-Bo; Josien, Hubert
Angewandte Chemie, 1995 , vol. 107, # 23/24 p. 2948 - 2950
反应条件
iodine cloride in tetrachloromethane; dichloromethane 48 h; Yield given;
参考文献
Josien, Hubert; Ko, Sung-Bo; Bom, David; Curran, Dennis P.
Chemistry - A European Journal, 1998 , vol. 4, # 1 p. 67 - 83
反应条件
1: tBuLi
2: nBuLi, I2
3: 63 percent / Et3SiH / trifluoroacetic acid
4: 69 percent / K2CO3, Bu4NBr / Pd(OAc)2
5: 1.) OsO4, (DHQD)2-Pyr, 2.) I2, CaCO3
6: 47 percent / ICl
7: 72 percent / aq. HI
8: 88 percent / NaH, LiBr / 1,2-dimethoxy-ethane; dimethylformamide
9: Me3SnSnMe3 / benzene / 70 °C / Irradiation
View Scheme
参考文献
Curran, Dennis P.; Ko, Sung-Bo; Josien, Hubert
Angewandte Chemie, 1995 , vol. 107, # 23/24 p. 2948 - 2950
