4-溴-1-[(4-甲基苯基)磺酰基]吡咯烷-3-酮合成路线 （共 5 条）
反应条件
Dess-Martin periodane in dichloromethane T=20°C;
参考文献
WO2008/12010 A1, ;
Page/Page column 66-67 ;
WO 2008/012010 A1
反应条件
bromine; acetic acid T=46 - 50°C; 0.0833333 h;
参考文献
Heterocycles, , vol. 41, # 7 p. 1389 - 1398
反应条件
1: 75 percent / NBS, H2O / dimethylsulfoxide 2: 81 percent / (n-Bu)3SnH / tetrahydrofuran / 5 h / Heating 3: 77 percent / PCC / CH2Cl2 / Ambient temperature 4: Br2, AcOH / 0.08 h / 46 - 50 °C View Scheme
参考文献
Heterocycles, , vol. 41, # 7 p. 1389 - 1398
反应条件
1: 80.5 percent / NaH / dimethylformamide / 1 h / Ambient temperature 2: 75 percent / NBS, H2O / dimethylsulfoxide 3: 81 percent / (n-Bu)3SnH / tetrahydrofuran / 5 h / Heating 4: 77 percent / PCC / CH2Cl2 / Ambient temperature 5: Br2, AcOH / 0.08 h / 46 - 50 °C View Scheme
参考文献
Heterocycles, , vol. 41, # 7 p. 1389 - 1398
反应条件
1: 77 percent / PCC / CH2Cl2 / Ambient temperature 2: Br2, AcOH / 0.08 h / 46 - 50 °C View Scheme
参考文献
Heterocycles, , vol. 41, # 7 p. 1389 - 1398
