1H-吲唑-6-羧酸甲酯合成路线 （共 17 条）
反应条件
acetic acid; sodium nitrite in water T=20°C; 5 h; Acidic aqueous solution;
参考文献
WO2008/61109 A2, ;
Page/Page column 29-30 ;
WO 2008/061109 A2
反应条件
sodium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
US2012/108619 A1, ;
Page/Page column 31-32 ;
反应条件
hydrogenchloride; potassium acetate; sodium nitrite in hexane; chloroform; water
反应条件
diazomethyl-trimethyl-silane in diethyl ether; toluene
参考文献
WO2009/152200 A1, ;
Page/Page column 81; 82 ;
反应条件
1: With lithium triethylborohydride in tetrahydrofuran T=-78°C; 1 h; 2: With sodium hydrogen sulphate; water in tetrahydrofuran Product distribution / selectivity;
参考文献
WO2009/32125 A1, ;
Page/Page column 112-113 ;
反应条件
sulfuric acid in methanol; water
参考文献
US6262040 B1, ;
US 6262040 B1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in methanol 16 h; Inert atmosphereReflux;
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
反应条件
methanol in diethyl ether; toluene Product distribution / selectivity;
参考文献
WO2009/32125 A1, ;
Page/Page column 111-112 ;
反应条件
1: sulfuric acid / |Reflux; |Molecular sieve 2: tin(ll) chloride / ethanol / 0.5 h / |Reflux 3: acetic acid; sodium nitrite / water 4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
反应条件
1: tin(ll) chloride / ethanol / 0.5 h / |Reflux 2: acetic acid; sodium nitrite / water 3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
