1H-吲唑-6-羧酸甲酯合成路线 （共 17 条）
反应条件
1: acetic acid; sodium nitrite / water 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid 2: sulfuric acid / |Reflux; |Molecular sieve 3: tin(ll) chloride / ethanol / 0.5 h / |Reflux 4: acetic acid; sodium nitrite / water 5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / methanol / 16 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Tetrahedron, , vol. 70, # 2 p. 318 - 326
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2.5 h; 2: With sodium hydroxide; water in tetrahydrofuran
参考文献
US2008/200535 A1, ;
Page/Page column 133 ;
US 20080200535 A1
反应条件
iodine; potassium hydroxide in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
PFIZER INC.
Patent: US2012/270893 A1, 2012 ;
Location in patent: Page/Page column 22-23 ;
反应条件
lithium hydroxide; water in tetrahydrofuran T=50°C; 4 h;
参考文献
SUNESIS PHARMACEUTICALS, INC.
Patent: WO2005/44817 A1, 2005 ;
Location in patent: Page/Page column 118-119 ;
反应条件
1: 1H-indazole-6-carboxylic acid methyl ester With sodium hexamethyldisilazane in tetrahydrofuran 2: methyl iodide Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/65508 A1, 2008 ;
Location in patent: Page/Page column 34 ;
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=60°C; 3 h;
参考文献
WO2009/32125 A1, ;
Page/Page column 112 ;
