2-羟甲基吡咯烷-1-羧酸丁酯合成路线 （共 14 条）
反应条件
triethylamine in dichloromethane 1 h;
参考文献
Molander, Gary A.; Romero, Jan Antoinette C.
Tetrahedron, 2005 , vol. 61, # 10 p. 2631 - 2643
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=20°C; 14 h;
参考文献
WO2004/58705 A2, ;
Page 38;39 ;
WO 2004/058705 A2
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran 1 h; Heating / reflux; 2: With methanol in tetrahydrofuran T=20°C;
参考文献
US2003/229226 A1, ;
Page 12-13 ;
反应条件
[Ru(η4-COD)(η3-methylallyl)2]; 2-(dicyclohexylphosphino)-1-(2-methoxyphenyl)-1H-imidazole; hydrogen in toluene T=160°C; P=37503.8 Torr; 24 h; AutoclaveInert atmosphere; Overall yield = 43 percentChromat.; regioselective reaction;
参考文献
Wu, Lipeng; Fleischer, Ivana; Jackstell, Ralf; Profir, Irina; Franke, Robert; Beller, Matthias
Journal of the American Chemical Society, 2013 , vol. 135, # 38 p. 14306 - 14312
反应条件
triethylamine in 1,4-dioxane; water 2 h; Ambient temperature;
参考文献
Hofmann, Thomas; Schieberle, Peter
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 6 p. 2270 - 2277
反应条件
in tetrahydrofuran; chloroform
参考文献
The Upjohn Company
Patent: US5137905 A1, 1992 ;
反应条件
1: in ethanol T=45°C; 0.166667 h; 2: With borane-THF in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
Chemistry - A European Journal, , vol. 20, # 6 p. 1530 - 1538
反应条件
1.1: thionyl chloride / methanol / 0 - 20 °C 1.2: 0 - 60 °C 2.1: triethylamine / dichloromethane / 3 h / 20 °C View Scheme
参考文献
WO2011/22508 A2, ;
WO 2011/022508 A2
反应条件
sodium tetrahydroborate
参考文献
Journal of the American Chemical Society, , vol. 132, # 40 p. 14027 - 14029
