1: sodium acetate hydrate / ethanol; H2O / 20 h / Heating 2: borane, (S)-2-amino-3-methyl-1,1-diphenyl-1-butanol <(S)-3> / tetrahydrofuran View Scheme

borane; (S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol in tetrahydrofuran Yields of byproduct given;

Pseudomonas cepacia lipase PSL-C in various solvent(s) T=30°C; 32 h; Enzymatic reaction;

1: With thionyl chloride in methanol T=20°C; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere; 3: With ammonia; ammonium chloride in water Inert atmosphere; optical yield given as percent eeenantioselective reaction;