N-甲氧基-N-甲基-3-苯基-丙酰胺合成路线 （共 39 条）
反应条件
1: phenylacetylene With n-butyllithium in tetrahydrofuran T=0°C; 2: N-methoxy-N-methyl-3-phenyl-propionamide in tetrahydrofuran T=0°C; 1 h; 3: With acetic acid in tetrahydrofuran; methanol; water T=0°C; Further stages.;
参考文献
Jackson, Mary M.; Leverett, Carolyn; Toczko, Jennifer F.; Roberts, John C.
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 5032 - 5035
反应条件
samarium diiodide; water; triethylamine in tetrahydrofuran T=23°C; 18 h; Inert atmosphere; chemoselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 136, # 6 p. 2268 - 2271
反应条件
Schwartz's reagent in tetrahydrofuran T=20°C; 0.333333 h;
参考文献
Journal of the American Chemical Society, , vol. 122, # 48 p. 11995 - 11996
Journal of the American Chemical Society, , vol. 129, # 11 p. 3408 - 3419
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78 - -40°C; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
反应条件
1: in tetrahydrofuran T=0°C; 3 h; 2: With water; ammonium chloride in tetrahydrofuran
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
Location in patent: Page/Page column 31 ;
WO 2012/100734 A1
反应条件
1: 1,2-dibromo-propane With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78 - 0°C; 2: N-methoxy-N-methyl-3-phenyl-propionamide in tetrahydrofuran; hexane T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane; water T=0°C;
参考文献
Tanaka, Yuta; Kanai, Motomu; Shibasaki, Masakatsu
Journal of the American Chemical Society, 2010 , vol. 132, # 26 p. 8862 - 8863
反应条件
1: 4-bromo-but-1-ene With iodine; magnesium in tetrahydrofuran 1.5 h; Heating; 2: N-methoxy-N-methyl-3-phenyl-propionamide in tetrahydrofuran 0.5 h; Heating;
参考文献
Kitamura, Mitsuru; Yoshida, Masayuki; Kikuchi, Takashi; Narasaka, Koichi
Synthesis, 2003 , # 15 p. 2415 - 2426
反应条件
in tetrahydrofuran T=0°C; Inert atmosphere;
参考文献
Clive, Derrick L. J.; Pham, Mai P.
Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1685 - 1690
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With trimethylaluminum in hexane; toluene
T=-10 - 20°C; 1 h; Reflux;
2: methyl β-phenylpropionate in toluene
T=20°C; 3 h;
参考文献
UNIVERSITY OF BRISTOL; AGGARWAL, Varinder, Kumar; COULTHARD, Mark, Graeme; ERB, William
Patent: WO2013/186550 A1, 2013 ;
Location in patent: Page/Page column 100; 101 ;
反应条件
1: 3-phenylpropionic acid With N-ethyl-N,N-diisopropylamine; [bis(2-methoxyethyl)amino]-sulfur trifluoride in N,N-dimethyl-formamide
T=0°C; 0.25 h;
2: N,O-dimethyl-hydroxylamine in N,N-dimethyl-formamide
T=0 - 20°C; 8 h; Further stages.;
参考文献
Tunoori, Ashok Rao; White, Jonathan M.; Georg, Gunda I.
Organic Letters, 2000 , vol. 2, # 25 p. 4091 - 4093
