N-甲氧基-N-甲基-3-苯基-丙酰胺合成路线 （共 39 条）
反应条件
1-methyl-1H-imidazole; N,N,N',N,-tetramethylethylenediamine; potassium carbonate in acetonitrile
T=0 - 5°C; 1 h;
参考文献
Nakatsuji, Hidefumi; Morimoto, Mami; Misaki, Tomonori; Tanabe, Yoo
Tetrahedron, 2007 , vol. 63, # 48 p. 12071 - 12080
反应条件
1: N,O-dimethyl-hydroxylamine With trimethylaluminum in toluene
T=-5 - 0°C;
2: methyl β-phenylpropionate in toluene
T=0 - 20°C;
参考文献
Trost, Barry M.; Machacek, Michelle R.; Faulk, Brian D.
Journal of the American Chemical Society, 2006 , vol. 128, # 20 p. 6745 - 6754
反应条件
1: 3-phenylpropionic acid With 4-(N,N-dimethlyamino)pyridine; nicotinic anhydride in dichloromethane
T=0°C; 0.166667 h;
2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane
T=0°C; 3 h;
参考文献
Funasaka, Setsuo; Mukaiyama, Teruaki
Bulletin of the Chemical Society of Japan, 2008 , vol. 81, # 1 p. 148 - 159
反应条件
isopropylmagnesium chloride in tetrahydrofuran
T=-10°C; 0.333333 h;
参考文献
Williams, J. Michael; Jobson, Ronald B.; Yasuda, Nobuyoshi; Marchesini, George; Dolling, Ulf-H.; Grabowski, Edward J. J.
Tetrahedron Letters, 1995 , vol. 36, # 31 p. 5461 - 5464
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; 1,3-bis-(diphenylphosphino)propane; caesium carbonate in toluene
T=150°C; indirect Wittig reaction; 72 h;
参考文献
Edwards, Michael G.; Williams, Jonathan M.J.
Angewandte Chemie - International Edition, 2002 , vol. 41, # 24 p. 4740 - 4743
反应条件
1: 3-phenyl-propionaldehyde With 1-hydroxy-pyrrolidine-2,5-dione; oxygen; [Co(O2CCH3)2]*4H2O in acetonitrile
T=20°C; P=760.051 Torr; 24 h; Molecular sieve;
2: N,O-dimethyl-hydroxylamine in acetonitrile
T=20°C; Molecular sieveInert atmosphere;
参考文献
Yao, Haoyi; Yamamoto, Kana
Chemistry - An Asian Journal, 2012 , vol. 7, # 7 p. 1542 - 1545
反应条件
sodium hydrogencarbonate in acetonitrile
T=20°C; Inert atmosphere;
参考文献
Yao, Haoyi; Tang, Yun; Yamamoto, Kana
Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5094 - 5098
反应条件
in tetrahydrofuran
T=-78°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With sodium hydrogencarbonate
2: trans-4-hydroxy-4-methyl-1-phenyl-1-penten-3-one With 1H-1,2,4-triazol; C6H10N3O2S(1+)*Cl(1-); N-ethyl-N,N-diisopropylamine in dichloromethane
T=40°C; 12 h;
参考文献
Chiang, Pei-Chen; Kim, Yoonjoo; Bode, Jeffrey W.
Chemical Communications, 2009 , # 30 p. 4566 - 4568
反应条件
in acetonitrile-D3
T=80°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Heller, Stephen T.; Sarpong, Richmond
Tetrahedron, 2011 , vol. 67, # 46 p. 8851 - 8859
