N-甲氧基-N-甲基-3-苯基-丙酰胺合成路线 （共 39 条）
反应条件
1: 1-Bromo-3-methyl-3-butene With iodine; magnesium in tetrahydrofuran
Heating;
2: N-methoxy-N-methyl-3-phenyl-propionamide in tetrahydrofuran
Heating;
参考文献
Kitamura, Mitsuru; Yoshida, Masayuki; Kikuchi, Takashi; Narasaka, Koichi
Synthesis, 2003 , # 15 p. 2415 - 2426
反应条件
1: cesium fluoride / toluene / 24 h / 0 - 20 °C
2: tetrabutyl ammonium fluoride / water; hexane; tetrahydrofuran / 2 h / 50 °C
3: oxoammonium salt; 2,6-dimethylpyridine / dichloromethane / 24 h / |Reflux
View Scheme
参考文献
Hamlin, Trevor A.; Kelly, Christopher B.; Leadbeater, Nicholas E.
European Journal of Organic Chemistry, 2013 , # 18 p. 3658 - 3661
反应条件
1.1: cesium fluoride / toluene / 0.17 h / 0 °C
1.2: 24 h / 0 - 20 °C
2.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran; hexane / 2 h / 50 °C
View Scheme
参考文献
Hamlin, Trevor A.; Kelly, Christopher B.; Leadbeater, Nicholas E.
European Journal of Organic Chemistry, 2013 , # 18 p. 3658 - 3661
反应条件
1: in tetrahydrofuran
T=0°C; 5 h; Heating / reflux;
2: With water; ammonium chloride in tetrahydrofuran
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/435 A1, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
1: 1-bromo-4-chloro-butane With magnesium in diethyl ether
0.25 h; Heating / reflux;
2: N-methoxy-N-methyl-3-phenyl-propionamide in tetrahydrofuran; diethyl ether
T=5 - 20°C; 4 h;
参考文献
Guillemont, Jerome Emile Georges; Dorange, Ismet; Lancois, David Francis Alain; Villalgordo-Soto, Jose Manuel; Ferdinand, Yvan Rene; Motte, Magali Madeleine Simone; Andries, Koenraad Jozef Lodewijk Marcel; Koul, Anil
Patent: US2010/63026 A1, 2010 ;
Location in patent: Page/Page column 25 ;
反应条件
Bu3SnLi in tetrahydrofuran
参考文献
Paleo, M. Rita; Calaza, M. Isabel; Grana, Paula; Sardina, F. Javier
Organic Letters, 2004 , vol. 6, # 6 p. 1061 - 1063
反应条件
samarium diiodide; water; triethylamine in tetrahydrofuran
T=23°C; 18 h; Inert atmosphere; chemoselective reaction;
参考文献
Szostak, Michal; Spain, Malcolm; Eberhart, Andrew J.; Procter, David J.
Journal of the American Chemical Society, 2014 , vol. 136, # 6 p. 2268 - 2271
反应条件
1: trans-5-bromo-2-pentene With iodine; magnesium in tetrahydrofuran
Heating;
2: N-methoxy-N-methyl-3-phenyl-propionamide in tetrahydrofuran
Heating;
参考文献
Kitamura, Mitsuru; Yoshida, Masayuki; Kikuchi, Takashi; Narasaka, Koichi
Synthesis, 2003 , # 15 p. 2415 - 2426
反应条件
1: tetrahydrofuran / 3 h / 0 °C
2: copper(ll) bromide / ethyl acetate; chloroform / 2 h / Reflux
View Scheme
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
WO 2012/100734 A1
