1: 1.) nBuLi, 2.) BF3*Et2O / 1.) hexane, THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h and -50 deg C, 1 h. 2: 96 percent / NaHg / methanol 3: N,N-diisopropylethylamine / CH2Cl2 / 0.25 h / 0 °C 4: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2; H2O / 0.5 h / Ambient temperature 5: 1.) 2,4,6-trichlorobenzoyl chloride, Et3N, 2.) 4-dimethylaminopyridine / 1.) toluene, room temperature, 2 h, 2.) toluene, overnight. 6: 31 percent / AgNO3, phosphate buffer, N-chlorosuccinimide / acetone / 0.17 h / Ambient temperature; pH=7 8: 80 percent / pyridinium poly(hydrogen fluoride) / tetrahydrofuran / 0 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2349612', constants.ctx, '0')">boron trifluoride diethyl etherate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />&nbsp;1.) 0 deg C, 1 h, 2.) room temperature, overnight.;&nbsp;<br /> &nbsp;