1-(3-氨基-4-甲基苯基)乙酮合成路线 （共 15 条）
反应条件
1: 1.) NaNO2, cc HCl 2.) CuCl2*2H2O, SO2 / 1.) AcOH, 5 deg C, 30 min 2.) AcOH, 0-5 deg C
2: cc NH4OH / tetrahydrofuran / Ambient temperature
View Scheme
参考文献
Fujikura; Miigata; Hashimoto; Imai; Takenaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 4092 - 4101
反应条件
hydrogenchloride; sulfur dioxide; sodium nitrite
1.) AcOH, 5 deg C, 30 min 2.) AcOH, 0-5 deg C; Yield given. Multistep reaction;
参考文献
Fujikura; Miigata; Hashimoto; Imai; Takenaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 4092 - 4101
反应条件
hydrogenchloride; acetic acid
参考文献
Ganguly; Le Fevre
Journal of the Chemical Society, 1934 , p. 848,851
Full Text Show Details
Lutz et al.
Journal of Organic Chemistry, 1947 , vol. 12, p. 617,680
反应条件
1: 1) diazotization 2) boiling 20percent H2SO4
2: 1) Mg / 1) THF 2) a) cooling, 2h b) reflux, 1h
View Scheme
参考文献
Phadnis, A. P.; Nanda, B.; Patwardhan, Sarita A.; Gupta, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1098 - 1102
参考文献
Keneford; Simpson
Journal of the Chemical Society, 1947 , p. 227,232
Full Text Show Details
Brady; Day
Journal of the Chemical Society, 1934 , p. 114,119
