3-氧代-5-苯基-戊酸乙酯合成路线 （共 34 条）
反应条件
1: aq. NaNO2, AcOH / 0.17 h / 5 - 7 °C 2: pyridine / CHCl3 / 12 h 3: 77 percent / polyphosphoric acid / Ambient temperature View Scheme
参考文献
Zee, Sheng-Hsu; Chou, Shan-Yen
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1994 , vol. 41, # 5 p. 573 - 578
反应条件
1: NaCH(CO2Et)COCH3 With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 0.5 h; Inert atmosphere;
2: benzyl bromide in tetrahydrofuran; hexane
T=0°C; 1.5 h; Inert atmosphere;
参考文献
Dewal, Mahender B.; Wani, Amit S.; Vidaillac, Celine; Oupicky, David; Rybak, Michael J.; Firestine, Steven M.
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 145 - 153
反应条件
in tetrahydrofuran
T=20°C;
参考文献
Zhou, Chunmei; Shao, Ying; Gibbs, Richard A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 10 p. 1417 - 1420
反应条件
niobium pentachloride in dichloromethane
T=27°C; 3.5 h;
参考文献
Yadav; Subba Reddy; Eeshwaraiah; Reddy
Tetrahedron, 2005 , vol. 61, # 4 p. 875 - 878
反应条件
n-butyllithium in tetrahydrofuran; hexane; water
参考文献
Beecham Group Limited
Patent: US4444981 A1, 1984 ;
反应条件
triethylamine; palladium diacetate in N,N-dimethyl-formamide
T=80°C; Heck reaction; 48 h;
参考文献
Fang, Xiang; Yang, Xueyan; Yang, Xianjin; Zhao, Min; Chen, Guorong; Wu, Fanhong
Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8231 - 8234
反应条件
1: With pyridine
T=0°C; 1 h;
2: With ethanol
2 h; Heating / reflux;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2007/51062 A2, 2007 ;
Location in patent: Page/Page column 113 ;
WO 2007/051062 A2
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=23°C;
参考文献
Bartrum, Hannah E.; Blakemore, David C.; Moody, Christopher J.; Hayes, Christopher J.
Journal of Organic Chemistry, 2010 , vol. 75, # 24 p. 8674 - 8676
反应条件
zinc in tetrahydrofuran
1) 30 deg C, 2 h, 2) reflux, 18 h;
参考文献
Kashima, Choji; Huang, Xin Cheng; Harada, Yukari; Hosomi, Akira
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 793 - 794
反应条件
zinc in tetrahydrofuran
1 h; Heating;
参考文献
Kashima, Choji; Kita, Isanobu; Takahashi, Katsumi; Hosomi, Akira
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 3 p. 723 - 726
