1: (S)-3-(4-fluorophenyl)-4-(phenylmethyl)-2-morpholinone With L-Selectridereg; in tetrahydrofuran T=-80 - -70°C; 2 h; 2: 3,5-bis-(trifluoromethyl)benzoyl chloride in tetrahydrofuran T=-80 - -70°C; 1.83333 h; 3: With acetic acid in tetrahydrofuran T=25 - 30°C;

1: (S)-3-(4-fluorophenyl)-4-(phenylmethyl)-2-morpholinone With L-Selectridereg; in tetrahydrofuran T=-80 - -70°C; 2 h; 2: 3,5-bis-(trifluoromethyl)benzoyl chloride in tetrahydrofuran T=-80 - -70°C; 1.83333 h;

1: (3S)-4-benzyl-3-(4-fluorophenyl)morpholin-2-one hydrochloride With sodium carbonate in water 2: With L-Selectridereg; in tetrahydrofuran T=-75 - -70°C; 3: 3,5-bis-(trifluoromethyl)benzoyl chloride in tetrahydrofuran T=-75 - -70°C;

in tetrahydrofuran; water

water; sodium hydrogencarbonate in toluene Product distribution / selectivity;

in toluene T=-80 - -60°C; Product distribution / selectivity;