三苯甲基坎地沙坦西来替昔酯合成路线 （共 12 条）
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in tetrahydrofuran T=20 - 65°C; 6 h; Product distribution / selectivity;
参考文献
Soldevilla Madrid, Nuria
Patent: US2009/247595 A1, 2009 ;
Location in patent: Page/Page column 4 ;
反应条件
copper(l) iodide; potassium carbonate; L-proline in dimethyl sulfoxide T=70°C; 3 h; Inert atmosphere;
参考文献
Wang, Ping; Zheng, Guo-Jun; Wang, Ya-Ping; Wang, Xiang-Jing; Li, Yan; Xiang, Wen-Sheng
Tetrahedron, 2010 , vol. 66, # 29 p. 5402 - 5406
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene T=80°C; 13 h; Product distribution / selectivity;
参考文献
RATIOPHARM GMBH
Patent: WO2006/63578 A2, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
triethylamine 1 h; Heating / reflux;
参考文献
WO2008/129077 A2, ;
Page/Page column 27-28 ;
参考文献
WO2006/134078 A1, ;
Page/Page column 21-22 ;
反应条件
1: triethylamine / dichloromethane / 3.75 h / 25 - 35 °C 2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 60 - 65 °C View Scheme
反应条件
methanol; zinc(II) chloride in butanone T=20 - 40°C; 2.5 h; Product distribution / selectivity;
参考文献
Soldevilla Madrid, Nuria
Patent: US2009/247595 A1, 2009 ;
Location in patent: Page/Page column 5-6 ;
反应条件
anhydrous sodium hydrogen carbonate in methanol; dichloromethane; water; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5578733 A1, 1996 ;
反应条件
hydrogenchloride in methanol; ethanol; hexane; dichloromethane; water; acetone
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6177587 B1, 2001 ;
反应条件
methanol 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
KRKA, D.D. NOVO MESTO
Patent: WO2007/42161 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
