(2S,4R)-双-叔丁基4-羟基吡咯烷-1,2-二甲酸酯合成路线 （共 9 条）
反应条件
in tetrahydrofuran T=55 - 60°C; 20.5 h;
参考文献
Tanaka, Ken-Ichi; Sawanishi, Hiroyuki
Tetrahedron Asymmetry, 1998 , vol. 9, # 1 p. 71 - 77
反应条件
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate in N,N-dimethyl acetamide T=55°C; 21 h;
参考文献
Brackmann, Farina; Schill, Heiko; De Meijere, Armin
Chemistry - A European Journal, 2005 , vol. 11, # 22 p. 6593 - 6600
反应条件
hydrogen; palladium on activated charcoal in 1,4-dioxane T=20°C; 24 h;
参考文献
Bellis, Evagelos; Kokotos, George
Tetrahedron, 2005 , vol. 61, # 36 p. 8669 - 8676
反应条件
in tetrahydrofuran T=60°C; 16 h; Inert atmosphere;
参考文献
He, Yu-Peng; Tan, Hao; Arve, Lars; Baumann, Sascha; Waldmann, Herbert; Arndt, Hans-Dieter
Chemistry - An Asian Journal, 2011 , vol. 6, # 6 p. 1546 - 1556
反应条件
1: 88 percent / Na2CO3 / H2O; dioxane 2: 80 percent / tetrahydrofuran / 20 - 60 °C View Scheme
参考文献
Picha, Jan; Vanek, Vaclav; Budesinsky, Milos; Mladkova, Jana; Garrow, Timothy A.; Jiracek, Jiri
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 256 - 275
反应条件
1: 84 percent / BF3*Et2O / CH2Cl2; cyclohexane / 24 h / 20 °C 2: 84 percent / H2 / Pd/C / dioxane / 24 h / 20 °C View Scheme
参考文献
Bellis, Evagelos; Kokotos, George
Tetrahedron, 2005 , vol. 61, # 36 p. 8669 - 8676
反应条件
1: Na2CO3 2: 86 percent / tetrahydrofuran / 55 - 60 °C View Scheme
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
反应条件
1-methyl-pyrrolidin-2-one; tetrapropylammonium perruthennate; 4 A molecular sieve in dichloromethane T=20°C; 3 h;
参考文献
Tamaki; Han; Hruby
Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3593 - 3596
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=20°C; Mitsunobu bromination; 15 h;
参考文献
Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453
