1-Boc-4-(4-氨基苯基)哌嗪合成路线 （共 14 条）
反应条件
1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C 2: hydrogen; palladium 10 on activated carbon / ethyl acetate; methanol / 6 h / 5171.62 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 75, p. 43 - 56
反应条件
potassium carbonate in acetonitrile 48 h; Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 8 p. 3086 - 3090
反应条件
hydrogenchloride; acetic acid T=20°C; 2 h;
参考文献
Berrade, Luis; Aisa, Barbara; Ramirez, Maria J.; Galiano, Silvia; Guccione, Salvatore; Moltzau, Lise Roman; Levy, Finn Olav; Nicoletti, Ferdinando; Battaglia, Giuseppe; Molinaro, Gemma; Aldana, Ignacio; Monge, Antonio; Perez-Silanes, Silvia
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3086 - 3090
反应条件
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C 3: trifluoroacetic acid / 0.25 h / 20 °C View Scheme
参考文献
Huang, Xiaohua; Shipps, Gerald W.; Cheng, Cliff C.; Spacciapoli, Peter; Zhang, Xingmin; McCoy, Mark A.; Wyss, Daniel F.; Yang, Xianshu; Achab, Abdelghani; Soucy, Kyle; Montavon, Donna K.; Murphy, Denise M.; Whitehurst, Charles E.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 8 p. 632 - 637
