(R)-5,5-二甲基-4-苯基-2-恶唑烷酮合成路线 （共 16 条）
反应条件
1: 5,5-dimethyl-4-phenyl-oxazolidin-2-one With (R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in 1,1-dimethylpropan-1-ol T=0°C; Resolution of racemate; 2: isobutyric anhydride in 1,1-dimethylpropan-1-ol T=0°C; 22 h; Resolution of racemate; Reagent/catalystTime; enantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 134, # 42 p. 17605 - 17612
反应条件
1: 1) copper bromide dimethylsulfide complex, (CH3)2S / 1) THF, -40 deg C, 10 min, 2) THF, -15 deg C, 15 min 2: 97 percent / LiOH*H2O / tetrahydrofuran; H2O / 1) 0 deg C, 1 h, 2) 0 deg C to room temperature View Scheme
参考文献
Tetrahedron, , vol. 55, # 11 p. 3337 - 3354
反应条件
1: 65 percent / pyridine / 1) 0 deg C, 10 min, 2) room temperature, overnight 2: 92 percent / K2CO3 / ethanol / 0.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 55, # 11 p. 3337 - 3354
反应条件
1: p-toluenesulfonic acid monohydrate / toluene / 24 h / Heating View Scheme
参考文献
Heterocycles, , vol. 65, # 1 p. 149 - 159
反应条件
1: 75 percent / tetrahydrofuran; diethyl ether / 30 h / Ambient temperature 2: 84 percent / t-BuOK / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 4 p. 387 - 398
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Heterocycles, , vol. 65, # 1 p. 149 - 159
