8-苄基-1,3,8-三氮杂-螺[4.5]葵-4-酮合成路线 （共 4 条）
反应条件
1: 92 percent / NH4Cl / ethanol; H2O / 48 h / Ambient temperature 2: 75 percent / H2SO4 / 5 h / Ambient temperature 3: 1.) conc. H2SO4, 2.) NaBH4 / 1.) reflux, 20 h, 2.) MeOH, 60 deg C, 1 h View Scheme
参考文献
Metwally, Kamel A.; Dukat, Malgorzata; Egan, Christina T.; Smith, Carol; DuPre, Ann; Gauthier, Colleen B.; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5084 - 5093
反应条件
1: 75 percent / H2SO4 / 5 h / Ambient temperature 2: 1.) conc. H2SO4, 2.) NaBH4 / 1.) reflux, 20 h, 2.) MeOH, 60 deg C, 1 h View Scheme
参考文献
Metwally, Kamel A.; Dukat, Malgorzata; Egan, Christina T.; Smith, Carol; DuPre, Ann; Gauthier, Colleen B.; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5084 - 5093
反应条件
sodium tetrahydroborate; sulfuric acid 1.) reflux, 20 h, 2.) MeOH, 60 deg C, 1 h; Yield givenMultistep reaction;
参考文献
Metwally, Kamel A.; Dukat, Malgorzata; Egan, Christina T.; Smith, Carol; DuPre, Ann; Gauthier, Colleen B.; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5084 - 5093
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal
P=2068.59 Torr; 8 h; Ambient temperature;
参考文献
Metwally, Kamel A.; Dukat, Malgorzata; Egan, Christina T.; Smith, Carol; DuPre, Ann; Gauthier, Colleen B.; Herrick-Davis, Katharine; Teitler, Milt; Glennon, Richard A.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 5084 - 5093
