2-苯基-缩苹果酸单乙基酯合成路线 （共 10 条）
反应条件
tetrahydrofuran anschliessend mit Acetylchlorid Umsetzen;
参考文献
Ireland; Marshall
Journal of the American Chemical Society, 1959 , vol. 81, p. 2907
反应条件
1: ethyl hydrogen phenylmalonate in N,N-dimethyl-formamide 2: ethyl iodide With potassium carbonate in N,N-dimethyl-formamide Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 73, # 19 p. 7486 - 7497
反应条件
potassium hydroxide in tetrahydrofuran
T=0°C; 5 h;
参考文献
TEXAS TECH UNIVERSITY
Patent: WO2008/150487 A2, 2008 ;
Location in patent: Page/Page column 17-21; 25 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-60 - 20°C;
参考文献
Volonterio, Alessandro; Zanda, Matteo
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7486 - 7497
反应条件
thionyl chloride; sodium hydrogencarbonate in ethanol; N,N-dimethyl-formamide
参考文献
University of Florida
Patent: US5223528 A1, 1993 ;
参考文献
Stefanowa
Godisnik Univ. SofiaChem.Abstr., 40 Chimija <1943/44> 147, 158, 169 1948 , p. 4156
反应条件
(i) LDA, (ii) /BRN= 385653/; Multistep reaction;
参考文献
Krapcho,A.P. et al.
Tetrahedron Letters, 1974 , # 32 p. 2721 - 2723
反应条件
1: 18.6 g / thionyl chloride / CH2Cl2 / 20 h / Ambient temperature
2: pyridine / CH2Cl2 / 0 °C
3: sodium hydroxide / aq. ethanol / Ambient temperature
View Scheme
参考文献
Turconi; Banfi; Schiavi; Donetti
Farmaco, 1991 , vol. 46, # 9 p. 999 - 1009
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 2 h
2: potassium hydroxide / ethanol / 1 h
View Scheme
参考文献
Hong, Suckchang; Lee, Jihye; Kim, Minsik; Park, Yohan; Park, Cheonhyoung; Kim, Mi-Hyun; Jew, Sang-Sup; Park, Hyeung-Geun
Journal of the American Chemical Society, 2011 , vol. 133, # 13 p. 4924 - 4929
反应条件
thionyl chloride in benzene
参考文献
University of Florida
Patent: US5223528 A1, 1993 ;
