(4-溴-2-甲基苯基)甲醇合成路线 （共 7 条）
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; HERNANDEZ, Andres S.; ELLSWORTH, Bruce A.; EWING, William R.; CHEN, Bin
Patent: WO2014/78608 A1, 2014 ;
Location in patent: Paragraph 00280 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 3 h;
参考文献
Allergan Sales, Inc.
Patent: US6369225 B1, 2002 ;
Location in patent: Page column 43, 119 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; dichloromethane T=-78 - 20°C; 2: With ammonium chloride in tetrahydrofuran; dichloromethane; water
参考文献
Wyeth
Patent: US2007/66628 A1, 2007 ;
Location in patent: Page/Page column 17 ;
反应条件
1: thionyl chloride / 1.5 h / Reflux 2: N,N-dimethyl-formamide / 20 - 25 °C / Inert atmosphere View Scheme
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
WO 2013/043232 A2
反应条件
pyridinium chlorochromate in dichloromethane 2.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1516 - 1531
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0 - 5°C;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 36 ;
WO 2010/015652 A2
反应条件
1: PCC / CH2Cl2 / 2.5 h
2: p-TsOH*H2O / benzene / 17 h / Heating
View Scheme
参考文献
Dawson, Marcia I.; Hobbs, Peter D.; Derdzinski, Krzysztof; Chan, Rebecca L.-S.; Gruber, John; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1516 - 1531
