4-溴-2-(羟基甲基)苄醇合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride; zinc(II) chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Garcia, Daniel; Foubelo, Francisco; Yus, Miguel
Heterocycles, 2009 , vol. 77, # 2 p. 991 - 1005
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
TRANSTECH PHARMA, INC.
Patent: WO2004/14844 A2, 2004 ;
Location in patent: Page 185-186 ;
WO 2004/014844 A2
反应条件
lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether a) RT, 1 h, b) reflux, 1.5 h;
参考文献
Posner; Li; White; Vinader; Takeuchi; Guggino; Dolan; Kensler
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4529 - 4537
反应条件
lithium borohydride in tetrahydrofuran; diethyl ether T=0 - 20°C; 44 h; Inert atmosphere;
参考文献
Moni, Lisa; Banfi, Luca; Basso, Andrea; Galatini, Andrea; Spallarossa, Martina; Riva, Renata
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 339 - 351
反应条件
Oxonereg;; 3,3'-diiodo-2,2',6,6'-tetramethoxy-4,4'-biphenyldicarboxylic acid in nitromethane T=30 - 35°C; 24 h; Overall yield = 86 percent;
参考文献
European Journal of Organic Chemistry, , # 12 p. 2445 - 2452
反应条件
Oxonereg;; 3,3'-diiodo-2,2',6,6'-tetramethoxy-4,4'-biphenyldicarboxylic acid in nitromethane T=30 - 35°C; 24 h; Overall yield = 86 percent;
参考文献
European Journal of Organic Chemistry, , # 12 p. 2445 - 2452
反应条件
oxalyl dichloride; dimethyl sulfoxide in dichloromethane
T=-78°C; 2 h;
参考文献
TRANSTECH PHARMA, INC.
Patent: WO2004/14844 A2, 2004 ;
Location in patent: Page 185-186 ;
WO 2004/014844 A2
反应条件
phosphorus tribromide in diethyl ether
T=0°C; 7 h; Reflux;
参考文献
Suzuki, Noriyuki; Kishimoto, Kaito; Yamazaki, Kohei; Kumamoto, Takuya; Ishikawa, Tsutomu; Margetic, Davor
Synlett, 2013 , vol. 24, # 19 p. 2510 - 2514
