6-氰基-1,2,3,4-四氢萘合成路线 （共 12 条）
反应条件
1: With AlCl3, aluminium chloride in Carbon disufide T=60°C; 16 h; 2: With hydrogenchloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; chloroform T=0°C;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
1: (5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid; acetyl chloride in methanol T=25°C; 10.25 h; Under dry nitrogen; 2: methyl 1,2,3,4-tetrahydro-6-naphthalenecarboxylate With dimethylaluminium amide
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 23 ;
反应条件
NiBr2(PPh3)2; triphenylphosphine; zinc in acetonitrile T=60 - 65°C; 0.5 h;
参考文献
Chambers, Mark R. I.; Widdowson, David A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1365 - 1366
反应条件
1: With 1-methyl-pyrrolidin-2-one; copper (I) cyanide T=130°C; 40 h; Under dry nitrogen; 2: With 1-methyl-pyrrolidin-2-one 3 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 21 ;
反应条件
1: para-dicyanobenzene With ammonia; sodium T=-33°C; 2: 1,4-dibromo-butane With ammonia T=-33°C; Further stages.;
参考文献
Panteleeva; Lukyanova; Pokrovsky; Shteingarts
Russian Chemical Bulletin, 2007 , vol. 56, # 6 p. 1110 - 1118
反应条件
hydrogenchloride; sodium nitrite Diazotization.Eintragen in eine aus Natriumcyanid,Kupfer(I)-chlorid und wss. Ammoniak hergestellte Loesung;
参考文献
Sergiewskaja; Nichamkina
Zhurnal Obshchei Khimii, 1945 , vol. 15, p. 940,943
Chem.Abstr., 1946 , p. 6453
反应条件
anhydrous copper sulphate; water; copper(II) sulfate
参考文献
v. Braun
Chemische Berichte, 1922 , vol. 55, p. 1708
反应条件
Behandlung des in Aether geloesten Reaktionsprodukts mit NaOH;
参考文献
Houben; Fischer
Chemische Berichte, 1933 , vol. 66, p. 339,344
Full Text Show Details
Houben
Chemische Berichte, 1930 , vol. 63, p. 2455,2461
反应条件
1,2,3,4-tetrahydro-naphthalene; nickel T=110 - 130°C; P=15200 Torr; Hydrogenation;
参考文献
v.Braun; Blessing; Zobel
Chemische Berichte, 1923 , vol. 56, p. 1990
Chemische Berichte, 1923 , vol. 56, p. 1999
参考文献
v. Braun
Chemische Berichte, 1922 , vol. 55, p. 1708
