4-(2-羟基乙氧基)-苯甲酸合成路线 （共 16 条）
反应条件
1: With methanol; sodium hydroxide; water T=80°C; 1 h; 2: With hydrogenchloride in water
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/101808 A1, 2006 ;
Location in patent: Page/Page column 30-31 ;
WO 2006/101808 A1
反应条件
1: With potassium carbonate in DMF (N,N-dimethyl-formamide) T=90°C; 7 h; 2: With potassium hydroxide in water T=90°C; 3 h;
参考文献
EP1405850 A1, ;
Page 8; 13-14 ;
反应条件
lipase in tetrahydrofuran; hexane; dichloromethane
参考文献
Nitto Denko Corporation
Patent: EP980868 A1, 2000 ;
反应条件
potassium hydroxide; potassium iodide in ethanol; water T=100°C; 5 h;
参考文献
Nakanishi, Sadahiro; Ueda, Mitsuru
Chemistry Letters, 2007 , vol. 36, # 3 p. 452 - 453
反应条件
1: 4-(2-hydroxyethoxy)-chlorobenzene With n-butyllithium; Mg(OCH2CH2OEt)2 in tetrahydrofuran T=-78°C; deprotonation; 0.25 h; 2: With Li-naphthalenide in tetrahydrofuran T=-78 - -50°C; lithium-halogen exchange; 0.333333 h; 3: carbon dioxide in tetrahydrofuran; diethyl ether Carboxylation;
参考文献
Salteris, Constantinos S.; Kostas, Ioannis D.; Micha-Screttas, Maria; Steele, Barry R.; Heropoulos, George A.; Screttas, Constantinos G.; Terzis, Aris
Journal of Organometallic Chemistry, 1999 , vol. 590, # 1 p. 63 - 70
反应条件
1: With potassium hydroxide 2: With hydrogenchloride
参考文献
EP1990339 A1, ;
Page/Page column 14-15 ;
反应条件
1: 2-(4-bromophenoxy)-1-ethanol With n-butyllithium; Mg(OCH2CH2OEt)2 in tetrahydrofuran bromine-lithium exchange, deprotonation; 2: carbon dioxide in tetrahydrofuran Carboxylation;
参考文献
Salteris, Constantinos S.; Kostas, Ioannis D.; Micha-Screttas, Maria; Steele, Barry R.; Heropoulos, George A.; Screttas, Constantinos G.; Terzis, Aris
Journal of Organometallic Chemistry, 1999 , vol. 590, # 1 p. 63 - 70
反应条件
potassium hydroxide in ethanol; water
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 155, p. 113 - 128
反应条件
1: alkali View Scheme
参考文献
DE412699 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1724
反应条件
sodium Erhitzen des Reaktionsprodukts mit wss. NaOH;
