5,6-二氟苯并[c][1,2,5]噁二唑1-氧化物合成路线 （共 7 条）
反应条件
1: With sulfuric acid; sodium nitrite in acetic acid T=0°C; 1 h; 2: With sodium azide in water 3: With acetic acid 2 h; Heating;
参考文献
Carta, Antonio; Paglietti, Giuseppe; Rahbar Nikookar, Mohammad E; Sanna, Paolo; Sechi, Leonardo; Zanetti, Stefania
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 355 - 366
反应条件
sodium hydroxide; sodium hypochlorite in methanol T=5°C;
参考文献
Leyva, Socorro; Castanedo, Victor; Leyva, Elisa
Journal of Fluorine Chemistry, 2003 , vol. 121, # 2 p. 171 - 175
反应条件
1: 24 percent / HNO3 / acetic acid / 4 h / 90 °C 2: 58 percent / CF3CO2H; NaNO2; aq. NaN3 / H2SO4 / 15 °C 3: 40 percent / acetic acid / 6 h / 100 - 110 °C View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: aq. HCl / 90 °C 2: 24 percent / HNO3 / acetic acid / 4 h / 90 °C 3: 58 percent / CF3CO2H; NaNO2; aq. NaN3 / H2SO4 / 15 °C 4: 40 percent / acetic acid / 6 h / 100 - 110 °C View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 87 percent / HCl / ethanol / 2 h / Heating 2: 1.) HCl, H2O, NaNO2, 2.) NaN3, AcONa / 1.) 0 deg C, 15 min, 2.) H2O 3: 57 percent / H2O / 2 h / Heating View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: 57 percent / triethylamine / CHCl3 / 20 °C 2: 30 percent / sodium dithionite / H2O; methanol / 2 h / 65 °C View Scheme
参考文献
Kotovskaya; Romanova; Charushin; Chupakhin
Russian Journal of Organic Chemistry, 2002 , vol. 38, # 7 p. 1046 - 1052
参考文献
Kotovskaya; Romanova; Charushin; Kodess; Chupakhin
Journal of Fluorine Chemistry, 2004 , vol. 125, # 3 p. 421 - 428
