(8CI)-2-(p-甲氧基苯基)-呋喃合成路线 （共 51 条）
反应条件
1: 2-(4-methoxy-phenyl)-furan With trichlorophosphate in 1,2-dichloro-ethane T=20°C; 0.0833333 h; 2: N,N-dimethyl-formamide in 1,2-dichloro-ethane T=80°C; 0.5 h; 3: T=0°C; 0.5 h; Product distribution / selectivity;
参考文献
Keio University
Patent: EP2022794 A1, 2009 ;
Location in patent: Page/Page column 22; 23 ;
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; tetrabutylammomium bromide; potassium carbonate in chloroform; water
T=80 - 100°C; 0.25 h;
参考文献
Bumagin; Veselov; Belov
Chemistry of Heterocyclic Compounds, 2014 , vol. 50, # 1 p. 19 - 25
Khim. Geterotsikl. Soedin., 2014 , vol. 50, # 1 p. 24 - 31,7
反应条件
1: furan With CdCl2*TMEDA; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexane
T=20°C; 2 h; Inert atmosphere;
2: 1-bromo-4-methoxy-benzene With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate in tetrahydrofuran; hexane
T=60°C; 18 h; Inert atmosphere;
参考文献
L'Helgoual'ch, Jean-Martial; Bentabed-Ababsa, Ghenia; Chevallier, Floris; Yonehara, Mitsuhiro; Uchiyama, Masanobu; Derdour, Aicha; Mongin, Florence
Chemical Communications, 2008 , # 42 p. 5375 - 5377
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in tetrahydrofuran; toluene
T=20°C; 1 h; Schlenk techniqueInert atmosphere;
参考文献
Giannerini, Massimo; Fananas-Mastral, Martin; Feringa, Ben L.
Nature Chemistry, 2013 , vol. 5, # 8 p. 667 - 672
反应条件
Pd(OAc)2/XPhos; cesium fluoride in ethylene glycol dimethyl ether
T=80°C; Stille coupling; 4 h; Inert atmosphere;
参考文献
Naber, John R.; Buchwald, Stephen L.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 7-8 p. 957 - 961
反应条件
caesium carbonate; palladium dichloride in acetonitrile
T=20°C; Substitution; 3 h;
参考文献
Kang, Suk-Ku; Lee, Sang-Woo; Ryu, Hyung-Chul
Chemical Communications, 1999 , # 20 p. 2117 - 2118
反应条件
palladium 10 on activated carbon; LiF in 1-methyl-pyrrolidin-2-one
T=140°C; Stille coupling; 24 h;
参考文献
Yabe, Yuki; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao
Tetrahedron, 2010 , vol. 66, # 45 p. 8654 - 8660
反应条件
[(pentacarbonyl)N(CH3)3Cr] in dichloromethane
T=0°C; 30 h;
参考文献
Nakamura, Masaki; Yamane, Motoki; Sakurai, Hidehiro; Narasaka, Koichi
Heterocycles, 2003 , vol. 59, # 1 p. 333 - 345
反应条件
carbon monoxide; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in dichloromethane
T=0°C; P=760 Torr; 30 h;
参考文献
Nakamura, Masaki; Yamane, Motoki; Sakurai, Hidehiro; Narasaka, Koichi
Heterocycles, 2003 , vol. 59, # 1 p. 333 - 345
反应条件
trifuran-2-yl-phosphane; sodium hydride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene
T=50°C; 24 h;
参考文献
Denmark, Scott E.; Baird, John D.; Regens, Christopher S.
Journal of Organic Chemistry, 2008 , vol. 73, # 4 p. 1440 - 1455
