6-氯吡啶并[3,2-d]嘧啶-4(1H)-酮合成路线 (共 7 条)
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238587 A1, 2012 ;
Location in patent: Page/Page column 16 ;
US 20120238587 A1
反应条件
1.1: sulfuric acid / 3.5 h / 70 °C 1.2: 20 °C / Cooling 2.1: ammonium chloride; iron / ethanol; water / 1 h / 60 °C 3.1: 18 h / 145 °C View Scheme
参考文献
WO2011/131741 A1, ;
WO 2011/131741 A1
反应条件
1: ammonium chloride; iron / ethanol; water / 1 h / 60 °C 2: 18 h / 145 °C View Scheme
参考文献
WO2011/131741 A1, ;
WO 2011/131741 A1
US2012/94976 A1, ;
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 0.67 h / 20 - 180 °C 2.1: ammonium hydroxide; water / 0.33 h / 20 °C 2.2: 3 h / 20 °C 3.1: 3 h / Reflux View Scheme
参考文献
US2012/238587 A1, ;
US 20120238587 A1
反应条件
thionyl chloride in DMF (N,N-dimethyl-formamide) 1.5 h; Heating / reflux;
参考文献
WO2005/58913 A1, ;
Page/Page column 36 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
3 h; Heating / reflux; Product distribution / selectivity;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 42 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
2 h; Heating / reflux;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 72 ;