4-[(叔丁氧羰基)氨基]烟酸合成路线 （共 8 条）
反应条件
1: With sodium hydroxide; water in 1,4-dioxane T=60°C; 1 h; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
TIBOTEC PHARMACEUTICALS LTD
Patent: WO2006/100310 A1, 2006 ;
Location in patent: Page/Page column 34 ;
反应条件
1: pyridin-4-yl-carbamic acid tert-butyl ester With tert.-butyl lithium in tetrahydrofuran; pentane T=-50 - -28°C; 1 h; 2: carbon dioxide in tetrahydrofuran; pentane 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/49604 A2, 2005 ;
Location in patent: Page/Page column 106 ;
WO 2005/049604 A2
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; water T=20°C; 3 h;
参考文献
ADVINUS THERAPEUTICS LIMITED; KHARUL, Rajendra; BHUNIYA, Debnath; MOOKHTIAR, Kasim A.; SINGH, Umesh; HAZARE, Atul; PATIL, Satish; DATRANGE, Laxmikant; THAKKAR, Mahesh
Patent: WO2013/42139 A1, 2013 ;
Location in patent: Page/Page column 80 ;
反应条件
tert.-butyl lithium in tetrahydrofuran T=-78°C;
参考文献
Chan, Laval; Jin, Haolun; Stefanac, Tomislav; Lavallee, Jean-Francois; Falardeau, Guy; Wang, Wei; Bedard, Jean; May, Suzanne; Yuen, Leonard
Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3023 - 3025
反应条件
in tetrahydrofuran; water
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
carbon dioxide in tetrahydrofuran; pentane
参考文献
ELI LILLY AND COMPANY
Patent: EP1140905 B1, 2003 ;
反应条件
in methanol; hexane 0.25 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/49604 A2, 2005 ;
Location in patent: Page/Page column 107 ;
WO 2005/049604 A2
反应条件
trifluoroacetic acid
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
