7-氟吡啶并[4,3-d]嘧啶-4(1h)-酮合成路线 （共 4 条）
反应条件
tetrafluoroboric acid; sodium nitrite 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h;
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 90percent H2SO4 / 3 h / 60 - 70 °C 2: 2.) 2M aq. NaOH / 1.) 170 deg C, 1.5 d, 2.) 90 deg C, 5 min 3: 57 percent / 50percent HBF4, NaNO2 / 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 2.) 2M aq. NaOH / 1.) 170 deg C, 1.5 d, 2.) 90 deg C, 5 min 2: 57 percent / 50percent HBF4, NaNO2 / 1.) 0 deg C, 2.5 h, 2.) -20 deg C, 16 h View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
thionyl chloride; N,N-dimethyl-formamide 8 h; Heating;
参考文献
Thompson, Andrew M.; Murray, Donna K.; Elliott, William L.; Fry, David W.; Nelson, James A.; Showalter, H.D. Hollis; Roberts, Bill J.; Vincent, Patrick W.; Denny, William A.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 24 p. 3915 - 3925
