N-Boc-5-氨基-2-氟吡啶合成路线 (共 12 条)
反应条件
1: (6-fluoro-pyridin-3-yl)-carbamic acid, tert-butyl ester With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane
T=-15 - -10°C; 3 h;
2: carbon dioxide in hexane
T=-70°C; 2 h;
参考文献
Zhang, Yinsheng; Huang, Yun; Huang, Che C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 7 p. 485 - 496
反应条件
in sodium hydroxide; diethyl ether; water
参考文献
Warner-Lambert Company
Patent: US6313292 B1, 2001 ;
US 6313292 B1