5-叔丁氧基羰基氨基-2-氟异烟酸合成路线 （共 14 条）
反应条件
in sodium hydroxide; diethyl ether; water
参考文献
Warner-Lambert Company
Patent: US6313292 B1, 2001 ;
US 6313292 B1
反应条件
1.1: 84 percent / KF / dimethylsulfoxide / 18 h / 70 °C
2.1: 70 percent / H2 / Raney Ni / ethyl acetate
3.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C
4.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C
4.2: diethyl ether
View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: 91 percent / various solvent(s) / 10 h / 40 - 45 °C
2.1: n-BuLi; TMEDA / hexane; various solvent(s) / 3 h / -15 - -10 °C
2.2: 64 percent / hexane; various solvent(s) / 2 h / -70 °C
View Scheme
参考文献
Zhang, Yinsheng; Huang, Yun; Huang, Che C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 7 p. 485 - 496
反应条件
1.1: 91 percent / various solvent(s) / 10 h / 40 - 45 °C
2.1: n-BuLi; TMEDA / hexane; various solvent(s) / 3 h / -15 - -10 °C
2.2: 64 percent / hexane; various solvent(s) / 2 h / -70 °C
View Scheme
参考文献
Zhang, Yinsheng; Huang, Yun; Huang, Che C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 7 p. 485 - 496
