formamide

1: 94 percent / H2, Na2SO4 / 5percent Pd/C / toluene 2: 88 percent / 1,2-dichloro-ethane / 16 h / Heating 3: 47 percent / TMEDA, BuLi / diethyl ether; hexane / 1.) -40 deg C, 16 h, 2.) -40 deg C to r.t., 1 h 4: 94 percent / H2O, TFA / CH2Cl2 / 14 h / Ambient temperature 5: 89 percent / 2-methoxy-ethanol / 12 h / Heating View Scheme

1: 83 percent / CsF / various solvent(s) / 18 h / 130 °C 2: 94 percent / H2, Na2SO4 / 5percent Pd/C / toluene 3: 88 percent / 1,2-dichloro-ethane / 16 h / Heating 4: 47 percent / TMEDA, BuLi / diethyl ether; hexane / 1.) -40 deg C, 16 h, 2.) -40 deg C to r.t., 1 h 5: 94 percent / H2O, TFA / CH2Cl2 / 14 h / Ambient temperature 6: 89 percent / 2-methoxy-ethanol / 12 h / Heating View Scheme

in 2-methoxy-ethanol 12 h; Heating;

1: 88 percent / 1,2-dichloro-ethane / 16 h / Heating 2: 47 percent / TMEDA, BuLi / diethyl ether; hexane / 1.) -40 deg C, 16 h, 2.) -40 deg C to r.t., 1 h 3: 94 percent / H2O, TFA / CH2Cl2 / 14 h / Ambient temperature 4: 89 percent / 2-methoxy-ethanol / 12 h / Heating View Scheme

1: 47 percent / TMEDA, BuLi / diethyl ether; hexane / 1.) -40 deg C, 16 h, 2.) -40 deg C to r.t., 1 h 2: 94 percent / H2O, TFA / CH2Cl2 / 14 h / Ambient temperature 3: 89 percent / 2-methoxy-ethanol / 12 h / Heating View Scheme

1: 94 percent / H2O, TFA / CH2Cl2 / 14 h / Ambient temperature 2: 89 percent / 2-methoxy-ethanol / 12 h / Heating View Scheme

thionyl chloride in DMF (N,N-dimethyl-formamide) 7 h; Heating / reflux;

thionyl chloride in dichloromethane; tert-butyl methyl ether; 1,2-dichloro-ethane

trichlorophosphate