1-(2-吡啶)-1H-吡唑-4-羧酸乙酯合成路线 （共 5 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=140°C;
参考文献
Warshakoon, Namal C.; Wu, Shengde; Boyer, Angelique; Kawamoto, Richard; Renock, Sean; Xu, Kevin; Pokross, Matthew; Evdokimov, Artem G.; Zhou, Songtao; Winter, Carol; Walter, Richard; Mekel, Marlene
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 21 p. 5687 - 5690
反应条件
potassium carbonate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in toluene T=110°C;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/171754 A1, 2008 ;
Location in patent: Page/Page column 100-101 ;
US 20080171754 A1
反应条件
in ethanol T=0 - 20°C; 24 h;
参考文献
Holzer, Wolfgang; Seiringer, Gertrud
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 865 - 872
反应条件
1: water; lithium hydroxide hydrate / ethanol; tetrahydrofuran / 7 h / 0 - 20 °C 2: triethylamine; diphenyl phosphoryl azide / 3 h / 90 °C 3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; VIEIRA, Eric
Patent: WO2011/89132 A1, 2011 ;
WO 2011/089132 A1
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; ethanol
T=0 - 20°C; 7 h;
参考文献
F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; VIEIRA, Eric
Patent: WO2011/89132 A1, 2011 ;
Location in patent: Page/Page column 96 ;
WO 2011/089132 A1
