(3R,7as)-3-叔丁基二氢吡咯并[1,2-c]噁唑-1,5(3h,6h)-二酮合成路线 (共 1 条)
反应条件
methanesulfonic acid in diethylene glycol dimethyl ether; toluene 14.5 h; Inert atmosphereRefluxDean-Stark; ConcentrationTimeReagent/catalystTemperatureSolvent;
参考文献
OPKO Health, Inc.; Wu, George G.; Werne, Gerald; Fu, Xiaoyong; Orr, Robert K.; Chen, Frank Xing; Cui, Jian; Sprague, Victoria M.; Zhang, Fucheng; Xie, Ji; Zeng, Liansheng; Castellanos, Louis Peter; Chen, Yuyin; Poirier, Marc; Mergelsberg, Ingrid
Patent: US2014/31549 A1, 2014 ;
Location in patent: Paragraph 0136; 0137; 0138 ;