1-甲基-1,2-环氧环己烷合成路线 （共 60 条）
反应条件
(i) CuCN, Et2O, (ii) /BRN= 102878/; Multistep reaction;
参考文献
Acker,R.-D.
Tetrahedron Letters, 1977 , # 39 p. 3407 - 3410
反应条件
methylmagnesium N-cyclohexylisopropylamide in toluene
T=0°C; 20 h;
参考文献
Mosset, Paul; Manna, Sukumar; Viala, Jacques; Falck, J.R.
Tetrahedron Letters, 1986 , vol. 27, # 3 p. 299 - 302
反应条件
1,3-dimethyl-imidazolidin-2-one; toluene-4-sulfonic acid in dichloromethane
T=20°C; 2 h; regioselective reaction;
参考文献
Chapman, Helen A.; Herbal, Karim; Motherwell, William B.
Synlett, 2010 , # 4 art. no. D37609ST, p. 595 - 598
反应条件
toluene-4-sulfonic acid in dichloromethane
T=20°C; 2 h; regioselective reaction;
参考文献
Chapman, Helen A.; Herbal, Karim; Motherwell, William B.
Synlett, 2010 , # 4 art. no. D37609ST, p. 595 - 598
反应条件
in dichloromethane
2 h; Ambient temperature;
参考文献
Sasaki, Kazuaki; Mori, Toshiharu; Doi, Yoshitaka; Kawachi, Akinori; Aso, Yoshio; et al.
Chemistry Letters, 1991 , # 3 p. 415 - 418
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; (1S,3R,4R)-3-(N-pyrrolidinyl)methyl-2-azabicyclo[2.2.1]heptane; lithium diisopropyl amide in tetrahydrofuran; hexane
T=0°C; Ring cleavage; 4 h;
参考文献
Soedergren, Mikael J.; Bertilsson, Sophie K.; Andersson, Pher G.
Journal of the American Chemical Society, 2000 , vol. 122, # 28 p. 6610 - 6618
反应条件
1: With n-butyllithium; diisopropylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; hexane
T=0°C; 4 h;
2: With ammonium chloride in tetrahydrofuran
Further stages.;
参考文献
Gayet, Arnaud; Bertilsson, Sophie; Andersson, Pher G.
Organic Letters, 2002 , vol. 4, # 22 p. 3777 - 3779
反应条件
recombinant Aspergillus niger epoxide hydrolase extra residues containing Pro221Ser/Phe244Cys/Leu249Phe/Leu215Phe/Thr317Phe/Thr318Val(Pro-Thr-Ala-Ser-Ala-Pro-His-Thr-Tyr-Arg-Glu-Phe-Ile)Leu349Val mutant expressing cell lysate in acetonitrile
T=30°C; pH=7.4; 4 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Reetz, Manfred T.; Zheng, Huabao
ChemBioChem, 2011 , vol. 12, # 10 p. 1529 - 1535
参考文献
Archer, Ian V. J.; Leak, David J.; Widdowson, David A.
Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8819 - 8822
反应条件
2,6-dimethylpyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene in toluene
-78 deg C, 3 h. then 24 deg C, 3 h.;
参考文献
Noyori, R.; Murata, S.; Suzuki, M.
Tetrahedron, 1981 , vol. 37, # 23 p. 3899 - 3910
