(2R,4r)-1-苄基-4-氨基-吡咯烷-2,4-二羧酸合成路线 （共 10 条）
反应条件
hydrogen; palladium hydroxide - carbon in acetic acid P=2280 Torr; 10 h; Ambient temperature;
参考文献
Tanaka; Sawanishi
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1641 - 1656
反应条件
hydrogenchloride; sodium hydroxide
1.) Et2O, 2.) THF, RT; Multistep reaction;
参考文献
Valli, Matthew J.; Schoepp, Darryle D.; Wright, Rebecca A.; Johnson, Bryan G.; Kingston, Ann E.; Tomlinson, Rosemarie; Monn, James A.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1985 - 1990
反应条件
hydrogenchloride
T=130°C; 24 h;
参考文献
Tanaka; Sawanishi
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1641 - 1656
反应条件
1: 63 percent / Et3N / CH2Cl2
2: 50 percent / 5 M aq. NaOH / methanol / Ambient temperature
View Scheme
参考文献
Tueckmantel, Werner; Kozikowski, Alan P.; Wang, Shaomeng; Pshenichkin, Sergey; Wroblewski, Jarda T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 601 - 606
反应条件
1: TsOH / toluene / Heating
2: 63 percent / Et3N / CH2Cl2
3: 50 percent / 5 M aq. NaOH / methanol / Ambient temperature
View Scheme
参考文献
Tueckmantel, Werner; Kozikowski, Alan P.; Wang, Shaomeng; Pshenichkin, Sergey; Wroblewski, Jarda T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 601 - 606
反应条件
1: 48 percent / 6 N HCl / 27.5 h / Heating
2: TsOH / toluene / Heating
3: 63 percent / Et3N / CH2Cl2
4: 50 percent / 5 M aq. NaOH / methanol / Ambient temperature
View Scheme
参考文献
Tueckmantel, Werner; Kozikowski, Alan P.; Wang, Shaomeng; Pshenichkin, Sergey; Wroblewski, Jarda T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 5 p. 601 - 606
反应条件
1: triethylamine / CH2Cl2 / 6 h / Heating
2: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, from -78 deg C to RT
3: ethanol; H2O / 24 h / 55 - 60 °C
4: 64 percent / 6 N aq. HCl / 24 h / 130 °C
View Scheme
参考文献
Tanaka; Sawanishi
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1641 - 1656
反应条件
1: thionyl chloride / 6 h / Heating
2: triethylamine / CH2Cl2 / 6 h / Heating
3: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, from -78 deg C to RT
4: ethanol; H2O / 24 h / 55 - 60 °C
5: 64 percent / 6 N aq. HCl / 24 h / 130 °C
View Scheme
参考文献
Tanaka; Sawanishi
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1641 - 1656
反应条件
1: ethanol; H2O / 24 h / 55 - 60 °C
2: 64 percent / 6 N aq. HCl / 24 h / 130 °C
View Scheme
参考文献
Tanaka; Sawanishi
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1641 - 1656
反应条件
1: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, from -78 deg C to RT
2: ethanol; H2O / 24 h / 55 - 60 °C
3: 64 percent / 6 N aq. HCl / 24 h / 130 °C
View Scheme
参考文献
Tanaka; Sawanishi
Tetrahedron Asymmetry, 1995 , vol. 6, # 7 p. 1641 - 1656
