1-噁螺[2.5]辛烷-6-羧酸乙酯合成路线 （共 4 条）
反应条件
potassium tert-butylate in dimethyl sulfoxide T=20°C; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/92887 A1, 2008 ;
Location in patent: Page/Page column 28 ;
WO 2008/092887 A1
反应条件
boron trifluoride diethyl etherate in hexane; dichloromethane T=-30°C; 2 h; Yield given. Title compound not separated from byproducts;
参考文献
Alonso, Francisco; Mico, Irene; Najera, Carmen; Sansano, Jose M.; Yus, Miguel; et al.
Tetrahedron, 1995 , vol. 51, # 37 p. 10259 - 10280
反应条件
Verkade nonionic superbase in acetonitrile T=0 - 20°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2008/92887 A1, ;
Page/Page column 28-29 ;
WO 2008/092887 A1
反应条件
in diethyl ether; ethanol 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 51, # 37 p. 10259 - 10280
