2-氟-3-羟甲基-4-碘吡啶合成路线 （共 4 条）
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 1 h; 2: With hydrogenchloride in ethanol
参考文献
WO2012/75383 A2, ;
Page/Page column 123 ;
反应条件
n-butyllithium; sodium borohydride; diisopropylamine in tetrahydrofuran; ethyl acetate
参考文献
North Carolina State University
Patent: US5496952 A1, 1996 ;
反应条件
sodium tetrahydroborate Yield given;
参考文献
Tetrahedron Letters, , vol. 36, # 44 p. 7995 - 7998
反应条件
1: 88 percent / i-Pr2NEt, DMAP / CH2Cl2 / Ambient temperature
2: 1.) n-BuLi / 1.) THF, -78 deg C
3: 39 percent / 3N HCl
View Scheme
参考文献
Comins, Daniel L.; Saha, Jayanta K.
Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7995 - 7998
