1,4-二-Boc-哌嗪-2-羧酸甲酯合成路线 （共 8 条）
反应条件
caesium carbonate in ethyl acetate; acetonitrile
参考文献
SYMPHONY EVOLUTION, INC.
Patent: US2011/82114 A1, 2011 ;
US 20110082114 A1
反应条件
methanol in dichloromethane T=2 - 20°C; 2 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/148853 A1, 2008 ;
Location in patent: Page/Page column 158 ;
WO 2008/148853 A1
反应条件
citric acid in 1,4-dioxane
参考文献
Microcide Pharmaceuticals, Inc.
Patent: US6399629 B1, 2002 ;
反应条件
1: sodium carbonate / tetrahydrofuran / 20 h / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 0 - 20 °C View Scheme
参考文献
AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong
Patent: WO2012/171506 A1, 2012 ;
WO 2012/171506 A1
反应条件
sodium tetrahydroborate; ethanol; calcium chloride T=0 - 20°C; 1.5 h;
参考文献
AGIOS PHARMACEUTICALS, INC.; CAO, Sheldon; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey; TAN, Xuefei; TRAVINS, Jeremy; YAN, Shunqi; YE, Zhixiong
Patent: WO2012/171506 A1, 2012 ;
Location in patent: Page/Page column 113 ;
WO 2012/171506 A1
反应条件
in 1,4-dioxane; hydrogenchloride
参考文献
SYMPHONY EVOLUTION, INC.
Patent: US2011/82114 A1, 2011 ;
US 20110082114 A1
反应条件
sodium hydroxide in methanol
参考文献
Microcide Pharmaceuticals, Inc.
Patent: US6399629 B1, 2002 ;
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C; 4 h;
参考文献
CEPHALON, INC.; BRESLIN, Henry J.; CURRY, Matthew A.; GINGRICH, Diane E.; LEARN, Keith S.; OTT, Gregory R.; WAGNER, Jason C.
Patent: WO2013/116291 A1, 2013 ;
Location in patent: Page/Page column 207; 208 ;
