3-甲基-5-苯基-4-异恶唑甲酸合成路线 （共 12 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water T=20°C; 2: With hydrogenchloride in water pH=4;
参考文献
Cheng, Huimin; Wan, Junting; Lin, Meng-I; Liu, Yingxue; Lu, Xiaoyun; Liu, Jinsong; Xu, Yong; Chen, Jianxin; Tu, Zhengchao; Cheng, Yih-Shyun E.; Ding, Ke
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2144 - 2153
反应条件
1: sodium acetate; glacial acetic acid; hydroxylamine hydrochloride 2: NaOH-solution View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 45 I, p. 466
反应条件
1: diethyl ether; pyridine 2: alcohol; hydroxylamine hydrochloride / Verseifen des entstandenen Aethylesters mit alkoh. Kalilauge View Scheme
参考文献
Chemische Berichte, , vol. 42, p. 3919
反应条件
(i) Et3N, PhNCO, benzene, (ii) (saponification); Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 89, p. 5461 - 5462
反应条件
1: aq.-ethanolic NaOH 2: diethyl ether 3: aqueous NaOH View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 83, p. 192,209
反应条件
ethanol; hydroxylamine hydrochloride Verseifen des entstandenen Aethylesters mit alkoh. Kalilauge;
参考文献
Chemische Berichte, , vol. 42, p. 3919
反应条件
(i) PhCO2Na, (ii) NaOH; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 27, p. 4305 - 4309
反应条件
1: 1. Cl-CO2Et, Et3N 2. NaBH4 / 1. THF, -10 deg C, 30 min 2. a. H2O, 5-10 deg C b. 3h, room temperature 2: 70 percent / Na2Cr2O7*2H2O, H2SO4 / dimethylsulfoxide / 1. 50 deg C 2. 1h 70 deg C View Scheme
参考文献
Heck, Reinhard; Ofenloch, Roland; Wolf, Roland
Synthesis, 1990 , # 1 p. 62 - 64
反应条件
sodium tetrahydroborate; chloroformic acid ethyl ester; triethylamine 1. THF, -10 deg C, 30 min 2. a. H2O, 5-10 deg C b. 3h, room temperature; Yield given. Multistep reaction;
参考文献
Heck, Reinhard; Ofenloch, Roland; Wolf, Roland
Synthesis, 1990 , # 1 p. 62 - 64
参考文献
Gazzetta Chimica Italiana, , vol. 45 I, p. 466
