4-[2-[5,6-二氢-5,5-二甲基-8-[[(三氟甲基)磺酰基]氧基]-2-萘基]乙炔基]苯甲酸乙酯合成路线 （共 24 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-78 - 25°C;
参考文献
Johnson, Alan T.; Wang, Liming; Gillett, Samuel J.; Chandraratna, Roshantha A. S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 573 - 576
反应条件
1: 80 percent / AlCl3, Br2 / CH2Cl2 / 70 °C 2: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 3: K2CO3 / methanol 4: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C 5: 77 percent / NaN(SiMe3)2 / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
1: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 2: K2CO3 / methanol 3: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C 4: 77 percent / NaN(SiMe3)2 / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
1: K2CO3 / methanol 2: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C 3: 77 percent / NaN(SiMe3)2 / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
1: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C 2: 77 percent / NaN(SiMe3)2 / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
sodium hexamethyldisilazane 1.) THF, -78 deg C, 2.) THF, from 0 deg C to RT; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 24 p. 4764 - 4767
反应条件
tert.-butyl lithium; Zinc chloride; tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran; pentane
参考文献
Allergan Sales, Inc.
Patent: US5958954 A1, 1999 ;
US 5958954 A
反应条件
n-butyllithium; Zinc chloride; tetrakis (triphenylphosphine) palladium (0) in tetrahydrofuran
参考文献
Allergan Sales, Inc.
Patent: US5958954 A1, 1999 ;
US 5958954 A
反应条件
tert.-butyl lithium; Zinc chloride in tetrahydrofuran; pentane
参考文献
Allergan Sales, Inc.
Patent: US5958954 A1, 1999 ;
US 5958954 A
