(1R,3r)-1,2,3,4-四氢-1-(3,4-亚甲基二氧基苯基)-9h-吡啶并[3,4-b]吲哚-3-羧酸甲酯合成路线 (共 18 条)
反应条件
carbonic acid dimethyl ester T=20°C; 23 h; Ionic liquid;
参考文献
RSC Advances, , vol. 4, # 3 p. 1204 - 1211
反应条件
trifluoroacetic acid
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 8 p. 1425 - 1428
反应条件
hydrogenchloride in water Pictet-Spengler cyclisation; 25 h; Reflux;
参考文献
Letters in Organic Chemistry, , vol. 7, # 4 p. 311 - 313
反应条件
1: thionyl chloride / 4 h / 40 °C 2: carbonic acid dimethyl ester / 6 h / 80 °C / |Ionic liquid View Scheme
参考文献
RSC Advances, , vol. 4, # 3 p. 1204 - 1211
反应条件
potassium carbonate in dichloromethane; ethyl acetate T=5 - 20°C;
参考文献
Xiao, Sen; Shi, Xiao-Xin; Xing, Jing; Yan, Jing-Jing; Liu, Shi-Ling; Lu, Wei-Dong
Tetrahedron Asymmetry, 2009 , vol. 20, # 18 p. 2090 - 2096
反应条件
1: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C 2: 1.1 percent / methanol / 16 h / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 6 p. 1505 - 1515
反应条件
1: 83 percent / triethylamine / CHCl3 / -10 °C 2: 70 percent / NH3 / methanol / 20 h / 45 °C View Scheme
参考文献
Beghyn, Terence B.; Charton, Julie; Leroux, Florence; Laconde, Guillaume; Bourin, Arnaud; Cos, Paul; Maes, Louis; Deprez, Benoit
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3222 - 3240
反应条件
1: 91 percent / sodium bicarbonate / CH2Cl2 / 1 h / 0 °C 2: 54 percent / methanol / 16 h / 50 °C View Scheme
参考文献
Daugan, Alain; Grondin, Pascal; Ruault, Cecile; Le Monnier de Gouville, Anne-Charlotte; Coste, Herve; Linget, Jean Michel; Kirilovsky, Jorge; Hyafil, Francois; Labaudinieret, Richard
Journal of Medicinal Chemistry, 2003 , vol. 46, # 21 p. 4533 - 4542