4-甲氧基-3-甲基联苯合成路线 （共 53 条）
反应条件
triphenylphosphine; Ni(II)/C in tetrahydrofuran
Kumada coupling; 1 h; Heating;
参考文献
Tasler, Stefan; Lipshutz, Bruce H.
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1190 - 1199
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; 8 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
1: para-iodoanisole With [PdCl2(1,3-bis(diphenylphosphino)propane)]; tBuCH2CH2B(H)NiPr2; triethylamine; potassium iodide in toluene
T=110°C; Suzuki coupling; 1 h; Inert atmosphere;
2: 3-methyliodobenzene With caesium carbonate in ethanol; water; toluene
T=90°C; Suzuki coupling; 15 h; Inert atmosphere;
参考文献
Marciasini, Ludovic; Richy, Nicolas; Vaultier, Michel; Pucheault, Mathieu
Chemical Communications, 2012 , vol. 48, # 10 p. 1553 - 1555
反应条件
potassium phosphate; 1,1'-bis(diphenylphosphanyl)ferrocenenickel(II) chloride in toluene
T=110°C; Suzuki-Miyaura Coupling; 24 h; Schlenk technique;
参考文献
Li, Xiao-Jian; Zhang, Jin-Ling; Geng, Yu; Jin, Zhong
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 5078 - 5084
反应条件
tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran
6 h; Heating;
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1137 - 1143
反应条件
tetrabutylammomium bromide; palladium diacetate in water
T=20°C; Suzuki-Miyaura coupling; 8 h;
参考文献
Basu, Basudeb; Biswas, Kinkar; Kundu, Sekhar; Ghosh, Sujit
Green Chemistry, 2010 , vol. 12, # 10 p. 1734 - 1738
反应条件
1: 4-methoxy-aniline With tert.-butylnitrite; boron trifluoride diethyl etherate in methanol
T=0°C; 0.5 h; Schlenk technique;
2: 3-methyl phenyl boronic acid in methanol
T=0 - 60°C; 5 h; Schlenk technique;
参考文献
Zong, Yan; Hu, Jiefeng; Sun, Peipei; Jiang, Xiaoqing
Synlett, 2012 , vol. 23, # 16 art. no. ST-2012-W0506-L, p. 2393 - 2396
反应条件
bis(carbene)-derived nickel(II)-pincer complex in tetrahydrofuran
T=20°C; Grignard coupling reaction; 96 h;
参考文献
Inamoto, Kiyofumi; Kuroda, Jun-Ichi; Sakamoto, Takao; Hiroya, Kou
Synthesis, 2007 , # 18 p. 2853 - 2861
反应条件
potassium phosphate; Ni(PCy3)2Cl2 in 1,4-dioxane
T=110°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Chen, Hu; Huang, Zhongbin; Hu, Xiaoming; Tang, Guo; Xu, Pengxiang; Zhao, Yufen; Cheng, Chien-Hong
Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 2338 - 2344
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; caesium carbonate; palladium dichloride in N,N-dimethyl-formamide
T=185°C; 20 h; Inert atmosphere;
参考文献
Ortgies, Dirk H.; Barthelme, Alexandre; Aly, Sara; Desharnais, Brigitte; Rioux, Steven; Forgione, Pat
Synthesis (Germany), 2013 , vol. 45, # 5 art. no. SS-2012-M0902-OP, p. 694 - 702
