对甲苯磺酸2-甲氧基乙酯合成路线 （共 28 条）
反应条件
tetrabutylammomium bromide in toluene Reflux;
参考文献
Dasari, Varaprasad; Srinivas, Rao V.; Rao, Sunil R.; Akula, Kalyan Chakravarthy; Dhamjewar, Ravi; Sanghvi, Yogesh S.
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 468 - 469
反应条件
sodium hydride; hydroquinone in N,N-dimethyl-formamide T=65°C; 16 h;
参考文献
TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson
Patent: WO2013/82324 A1, 2013 ;
Location in patent: Paragraph 00131 ;
反应条件
potassium carbonate in acetonitrile Heating;
参考文献
Chang, Sung-Youn; Choi, Jeung Soon; Jeong, Kyu-Sung
Chemistry - A European Journal, 2001 , vol. 7, # 12 p. 2687 - 2697
反应条件
sodium hydride in pyridine T=20°C; 2 h; Product distribution / selectivity;
参考文献
US2008/306308 A1, ;
Page/Page column 7-8 ;
反应条件
sodium methylate 1.) 4 h, refux, 2.) overnight, room temperature;
参考文献
Houghton, Roy P.; Morgan, Alan D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 756 - 758
反应条件
potassium carbonate in acetonitrile 6 h; Reflux;
参考文献
Shenzhen Salubris Pharmaceuticals Co., Ltd.; Shanghai Institute of Pharmaceutical Industry; LI, Jianqi; ZHANG, Zixue; XIE, Peng; ZHANG, Qingwei
Patent: EP2592083 A1, 2013 ;
Location in patent: Paragraph 0258 ;
反应条件
potassium carbonate in dimethyl sulfoxide
T=20°C; 72 h;
参考文献
FMC CORPORATION
Patent: WO2005/36961 A2, 2005 ;
Location in patent: Page/Page column 54-55 ;
反应条件
sodium hydride
1.) THF, reflux, overnight, 2.) THF, reflux, 1 d; Yield given. Multistep reaction;
参考文献
Dale, Johannes; Fredriksen, Siw B.
Acta Chemica Scandinavica, 1992 , vol. 46, # 3 p. 271 - 277
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80 - 100°C; 3 h;
参考文献
Buchman; Scozzie; Ariyan; Heilman; Rippin; Pyne; Powers; Matthews
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1398 - 1405
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=160°C; 0.333333 h; Microwave irradiationInert atmosphere;
参考文献
Wolfe, Amanda L.; Duncan, Katharine K.; Lajiness, James P.; Zhu, Kaicheng; Duerfeldt, Adam S.; Boger, Dale L.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 17 p. 6845 - 6857
