反应条件
1: 1.) lithium diisopropylamide; 2.) n-BuLi / 1.) THF, -78 degC, 2 h; 2.) THF/hexane, room temperature, 2.5 h
2: 15 percent / 1.) hydrogen; 2.) LiAlH4 / 1.) 5percent Pd-C / 1.) AcOH, room temperature, 12 h; 2.) THF, 1 h, room temperature
3: 72 percent / p-TsCl, pyridine / 4 h, room temperature, 3 h, reflux
View Scheme
参考文献
Tomioka; Ishiguro; Koga
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 10 p. 4333 - 4337
