2-氨基-4,6-二氯-5-甲酰氨基嘧啶合成路线 （共 11 条）
反应条件
1: T=50 - 55°C; 3 h; 2: in toluene T=50°C; under reduced pressure;
参考文献
Lonza AG
Patent: EP1188750 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
sodium hydroxide; trichlorophosphate in N-methyl-acetamide; water
反应条件
formic acid in water; toluene
反应条件
sodium hydroxide; phosphoric acid; trichlorophosphate in N-methyl-acetamide; water; toluene
反应条件
in phosphate buffer Hydrolysis; pH=3.2; 4 h; Heating;
参考文献
Daluge, Susan M.; Martin, Michael T.; Sickles, Barry R.; Livingston, Douglas A.
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 1-2 p. 297 - 327
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=50°C; 0.75 h; 2: 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride T=70 - 90°C; 17.45 - 20.45 h; 3: With sodium hydroxide; water T=20 - 97°C; pH=0.5 - 4.0; 4 - 8 h; Product distribution / selectivity;
参考文献
DEGUSSA AG
Patent: WO2005/68438 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
sodium hydroxide; phosphoric acid; water T=100°C; pH=4; 4 h; Product distribution / selectivity;
参考文献
WO2005/68438 A1, ;
Page/Page column 10 ;
反应条件
hydrogenchloride in ethanol; water Hydrolysis; 6 h; Heating;
参考文献
Daluge, Susan M.; Martin, Michael T.; Sickles, Barry R.; Livingston, Douglas A.
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 1-2 p. 297 - 327
反应条件
1: 83 percent / Et3N / ethanol / 7 h / Heating 2: 60 percent / butan-1-ol / 21 h / 130 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 19, # 1-2 p. 297 - 327
反应条件
sodium hydroxide; triethylamine in 2-methyl-propan-1-ol
参考文献
Lonza AG
Patent: US6137007 A1, 2000 ;
