2-甲基-4-苯基-3-丁炔-2-醇合成路线 （共 97 条）
反应条件
sodium hydroxide; copper(l) iodide; tetra-(n-butyl)ammonium iodide; bis-triphenylphosphine-palladium(II) chloride in toluene T=80°C; Sonogashira coupling; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 66, # 5 p. 1910 - 1913
反应条件
{(Pd{Fe(.eta.5-C5H5)(.eta.5-C5H3C(CH3)=NC6H4CH3-4)}(.mu.-Cl))2}; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetonitrile T=110°C; 16 h; Inert atmosphere;
参考文献
Hu, Hao; Yang, Fan; Wu, Yangjie
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10506 - 10511
反应条件
hydrogenchloride; copper; copper(l) chloride; calcium chloride in diethyl ether; Petroleum ether T=5°C; 1 h;
参考文献
Mesnard, Danielle; Bernadou, Francoise; Miginiac, Leone
Journal of Chemical Research, Miniprint, 1981 , # 9 p. 3216 - 3245
反应条件
sodium hydroxide; copper(l) iodide; tetra-(n-butyl)ammonium iodide; bis-triphenylphosphine-palladium(II) chloride in toluene T=80°C; Sonogashira coupling; 24 h;
参考文献
Chow; Wan; Low; Yeung
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1910 - 1913
反应条件
{(Pd{Fe(.eta.5-C5H5)(.eta.5-C5H3C(CH3)=NC6H4CH3-4)}(.mu.-Cl))2}; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetonitrile T=110°C; 16 h; Inert atmosphere;
参考文献
Hu, Hao; Yang, Fan; Wu, Yangjie
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10506 - 10511
反应条件
1: 2-hydroxy-2-methyl-4-phenyl-3-butyne With (o,o'-biphenylenedioxy)methylaluminium in hexane; dichloromethane T=20°C; 0.5 h; 2: phenylpropargyl aldehyde in hexane; dichloromethane T=20°C; Meerwein-Ponndorf-Verley alkynylation; 1 h;
参考文献
Ooi, Takashi; Miura, Tomoya; Ohmatsu, Kohsuke; Saito, Akira; Maruoka, Keiji
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3312 - 3319
反应条件
(o,o'-biphenylenedioxy)methylaluminium 1.) CH2Cl2, RT, 30 min, 2.) CH2Cl2, RT, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ooi; Miura; Maruoka
Journal of the American Chemical Society, 1998 , vol. 120, # 41 p. 10790 - 10791
反应条件
sodium hydroxide; copper(l) iodide; tetra-(n-butyl)ammonium iodide; bis-triphenylphosphine-palladium(II) chloride in toluene T=80°C; Sonogashira coupling; 24 h;
参考文献
Chow; Wan; Low; Yeung
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1910 - 1913
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; silica gel in dimethyl sulfoxide T=20 - 110°C; 0.05 h; Inert atmosphereMicrowave irradiation;
参考文献
Wu, Liansheng; Shi, Xiaokang; Xu, Xiaoyun; Liang, Fen; Huang, Guosheng
Journal of Chemical Sciences, 2011 , vol. 123, # 5 p. 697 - 702
反应条件
sodium hydroxide; copper(l) iodide; tetra-(n-butyl)ammonium iodide; bis-triphenylphosphine-palladium(II) chloride in toluene T=80°C; Sonogashira coupling; 24 h;
参考文献
Chow; Wan; Low; Yeung
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1910 - 1913
