甲基 4-(甲氧基甲基)苯酸酯合成路线 （共 11 条）
反应条件
1: p-methoxymethylbenzoic acid methyl ester With ammonia; lithium; tert-butyl alcohol in tetrahydrofuran T=-65 - 15°C; Birch Reduction; 0.916667 h; Inert atmosphere; 2: methyl iodide With ammonium chloride in tetrahydrofuran T=-65°C; Birch Reduction; 0.0833333 h; Inert atmosphere;
参考文献
Fretz, Samuel J.; Hadad, Christopher M.; Hart, David J.; Vyas, Shubham; Yang, Dexi
Journal of Organic Chemistry, 2013 , vol. 78, # 1 p. 83 - 92
反应条件
1: p-methoxymethylbenzoic acid methyl ester With ammonia; lithium; tert-butyl alcohol in tetrahydrofuran T=-65 - 15°C; Birch Reduction; 0.916667 h; Inert atmosphere; 2: methyl iodide With ammonium chloride in tetrahydrofuran T=-65°C; Birch Reduction; 0.0833333 h; Inert atmosphere;
参考文献
Fretz, Samuel J.; Hadad, Christopher M.; Hart, David J.; Vyas, Shubham; Yang, Dexi
Journal of Organic Chemistry, 2013 , vol. 78, # 1 p. 83 - 92
反应条件
1: 94 percent / LiAlH4 / diethyl ether 2: 89 percent / SOCl2 / CH2Cl2 3: 91 percent / HNO3 / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
nitric acid in dichloromethane T=20°C; 24 h;
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
1: 94 percent / LiAlH4 / diethyl ether 2: 8 percent / HNO3 / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
1: p-methoxymethylbenzoic acid methyl ester With ammonia; lithium; tert-butyl alcohol in tetrahydrofuran T=-65 - 15°C; Birch Reduction; 0.916667 h; Inert atmosphere; 2: methyl iodide With ammonium chloride in tetrahydrofuran T=-65°C; Birch Reduction; 0.0833333 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 78, # 1 p. 83 - 92
反应条件
1: 94 percent / LiAlH4 / diethyl ether
2: 79 percent / HNO3 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
1: 94 percent / LiAlH4 / diethyl ether
2: 89 percent / SOCl2 / CH2Cl2
View Scheme
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
反应条件
1: 94 percent / LiAlH4 / diethyl ether
2: 80 percent / HNO3 / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Strazzolini, Paolo; Runcio, Antonio
European Journal of Organic Chemistry, 2003 , # 3 p. 526 - 536
