1-(Cbz-氨基)环己甲酸合成路线 （共 7 条）
反应条件
sodium hydroxide in water 2 h;
参考文献
Bayer Corporation
Patent: US6353006 B1, 2002 ;
Location in patent: Page column 29 ;
US 6353006 B1
反应条件
4-methyl-morpholine; sodium tetrahydroborate; isobutyl chloroformate in ethylene glycol dimethyl ether; water T=4 - 20°C;
参考文献
Bayer Corporation
Patent: US6353006 B1, 2002 ;
Location in patent: Page column 30 ;
US 6353006 B1
反应条件
1: (i) Et3N, ClCO2Et, THF, (ii) NH3 2: H2 / Pd-C / methanol; H2O View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 5, p. 531 - 540
反应条件
ethylenediaminetetraacetic acid; phenyl-methyl-sulfonyl fluoride; water in aq. phosphate buffer T=30°C; Microbiological reactionEnzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Maurs, Michele; Acher, Francine; Azerad, Robert
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 22 - 26
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran
参考文献
Wang, Boyuan; Zhang, Wei; Zhang, Leilei; Du, Da-Ming; Liu, Gang; Xu, Jiaxi
European Journal of Organic Chemistry, 2008 , # 2 p. 350 - 355
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Schaefer, Gabriel; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 5 p. 1526 - 1529
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Schaefer, Gabriel; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 5 p. 1526 - 1529
